Study Finds CT Scans Are Effective Tool In Detecting Coronary Artery Disease

The Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography (CORE-64) Trial - conduct with researchers at nine transnational centers, as well as Beth Israel Deaconess Medical Center - studied 291 patients who be programmed to suffer convey coronary angiography all for suspected or unknown coronary artery bug. The den found that 64-slice multidetector CT angiography be importantly accurate contained by detect blockage of greater than 50 percent, subsequent to a ache of 85 percent and a specificity of 90 percent. The noninvasive exam was comparable in precision to invasive angiography in its dexterity to identify patients to be referred for angioplasty or bypass surgery.

"This study show that patients with minimal to intermediate stake of coronary blockages be promising to bonus from a non-invasive scan," said Melvin Clouse, MD, a radiologist at BIDMC and one of two principal consideration investigators. "The study suggest that that CT angiography may sooner or next replace other non-invasive test that rely against let-up of blood tide to the heart to diagnose arterial challenge." "CT angiography may indeed replace cardiac catheterization and vanguard further arbitration including risk factor modification/medical psychoanalysis, catheter-based, or surgical revascularization," said Roger Laham, MD, a BIDMC cardiologist and co-principal investigator. "This herald a untried and budding phase in diagnostic cardiac imaging with cardiologists and radiologists valid both to deliver leaders chariness to our patients." A second trial, The Assessment by Coronary Computed Tomographic Angiography of Individuals UndeRgoing InvAsive Coronary AngiographY (ACCURACY) Trial compare 64-row coronary count tomographic angiography (CCTA) to quantitative coronary angiography (QCA).

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Sixteen institution perform CCTA on 232 patients with classic or atypical chest pain prior to invasive coronary angiography. Findings were afterwards compared to those of QCA, the mention usual nearly new to quantify the results of the invasive coronary angiography.

A unqualified of 82 blockages greater than 50 percent in 49 patients and 31 blockages greater than 70 percent were detect in 28 patients by QCA. Per-patient sensitivity and specificity of CCTA were 93 percent and 82 percent, respectively, for blockages greater than 50 percent, and 91 percent and 84 percent for blockages greater than 70 percent. In decoration, gloomy predictive advantage was 97 to 99 percent.

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Beth Israel Deaconess Medical Center

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